教授
卫生毒理学系
leishi@lzu.edu.cn
2003.09-2007.06 河北北方学院,动物科技学院,学士
2007.09-2010.06 华中农业大学,农业微生物学国家重点实验室,硕士
2011.01-2014.11 德国慕尼黑大学,病理学研究所,博士(Dr.rer.nat)
2015.01-2021.01 Cancer Research UK Manchester Institute/英国曼彻斯特大学,博士后
2021.05-至今 beat365正版唯一,教授,独立PI
2021.12-至今 bet356官网在线网址科学技术发展研究院,副院长
研究方向:
主持或参与科研项目:
1.国家自然基金面上项目,82273001,2023-2026,主持
2.甘肃省重点研发项目,23YFWA0008, 2023-2025,主持
3. Cancer Research UK Core Funding,英国癌症研究院重大项目,C5759/A20971,10万英镑,主持
4.双一流高校人才建设经费,561121202,主持
5.甘肃省青年博士基金,2022QB-006,主持
6.bet356官网在线网址医学部优秀青年支持计划(A类支持)2022-2025
7.bet356官网在线网址医学研究生培养创新发展项目研究生全英文课程建设项目,主持
8.家畜疫病病原生物学国家重点实验室开发基金,2023-2025,主持
9.指导研究生主持甘肃省优秀研究生“创新之星”项目1项、指导本科生主持“国家级大学生创新创业训练计划” 1项、指导bet356官网在线网址生命科学学院本科生主持“bet356官网在线网址大学生创新创业计划” 1项
发表主要论文或专著:
1. Kaixin Yang*, Yinan Xiao*, Linghui Zhong, Wenyang Zhang, Peng Wang, Yaru Ren and Lei Shi. p53-regulated lncRNAs in cancers: from proliferation and metastasis to therapy. Cancer Gene Therapy. 2023. September. doi.org/10.1038/s41417-023-00662-7 (通讯作者,JCR一区,影响因子6.4).
2. Kaixin Yang*, Wenyang Zhang*, Linghui Zhong*, Yinan Xiao*, Sudhakar Sahoo, Mateo Fassan, Kang Zeng, Peter Magee, Michela Garofalo, Lei Shi. Long non-coding RNA HIF1A-As2 and MYC form a double positive feedback loop to promote cell proliferation and metastasis in KRAS-driven non-small cell lung cancer. Cell Death and Differentiation. 2023 Apr 11;1-17. doi: 10.1038/s41418-023-01160-x (通讯作者,JCR一区,影响因子12.07,该成果被人民日报和科学网等媒体报道).
3. Yushan Huang*, Longchang Jiang*, Yang Liu, Lixian Liu, Jungling Wang#, Lei Shi#. Long non-coding RNAs in virus-related cancers. Reviews in Medical Virology. 2022;e2364. Doi:10.1002/rmv.2364 (通讯作者, JCR一区, 影响因子11.043).
4. Kaixin Yang, Chengyun Li, Yang Liu, Xueyan Gu, Longchang Jiang#, Lei Shi#. Prognostic and immunotherapeutic roles of KRAS in Pan-Cancer. Cells. 2022, 11, 1427. Doi.org/10.3390/cells11091427 (通讯作者, JCR二区, 影响因子7.66).
5. Lei Shi, Peter Magee, Matteo Fassan, Sudhakar Sahoo, Hui Sun Leong, Dave Lee, Robert Sellers, Laura Brulle-Sumare, Stefano Cairo, Tiziana Monteverde, Stefano Volinia, Duncan Smith, Gianpiero Di Leva, Francesca Galuppini, Athanasios Paliouras, Kang Zeng, Raymond O'Keefe and Michela Garofalo. A KRAS-responsive long non-coding RNA controls microRNA processing. Nature Communications. 2021. 12:2038.doi.org/10.1038/s41467-021-22337 (JCR一区, 影响因子17.694).
6. Lucy Ginn, Manuela La Montagna, Qinghua Wu, Lei Shi. Diverse roles of long non-coding RNA in viral diseases. Reviews in Medical Virology. November 27 2020.DOI:10.1002/RMV.2198 (通讯作者, 封面故事, JCR一区, 影响因子11.043).
7. Athanasios R. Paliouras*, Marta Buzzetti*, Lei Shi*, Ian J. Donaldson, Peter Magee, Sudhakar Sahoo, Hui-Sun Leong, Matteo Fassan, Matthew Carter, Gianpiero Di Leva, Matthew Krebs, Fiona Blackhall, Christine M. Lovly and Michela Garofalo. Vulnerability of drug-resistance EML4-ALK rearranged lung cancer to transcriptional inhibition. EMBO Molecular Medicine. 2020 Jun 17; e110099. Doi: 10.15252/emmm.201911099 (并列第一作者,JCR一区, 影响因子12.131).
8. Lei Shi, Justin Middleton, Young-Jun Jeon, Peter Magee, Dario Veneziano, Alessandro Lagana, Hui-Sun Leong, Sudhakar Sahoo, Matteo Fassan, Richard Booton, Rajesh Shan, Philip A.J. Crosbie and Michela Garofalo. KRAS induces lung tumorigenesis through microRNAs modulation. Cell Death & Disease. 2018 Feb 13; 9(2):219 (JCR一区, 影响因子9.685).
9. Lei Shi, Rene Jackstadt, Helge Siemens, Huihui Li, Thomas Kirchner, Heiko Hermeking. p53-induced miR-15a/16-1 and AP4 form a double-negative feedback loop to regulate epithelial-mesenchymal transition and metastasis in colorectal cancer. Cancer Research. 2014 Jan 15; 74(2): 532-42(JCR一区,影响因子13.312).
10. Srivatsava Naidu*, Lei Shi*, Peter Magee, Justin D. Middleton, Alessandro Lagana, Sudhakar Sahoo, HuiSun Leong, Melanie Galvin, Kristopher Frese, Caroline Dive, Vincenza Guzzardo, Metteo Fassan, Michela Garofalo, PDGFR-modulated miR-23b cluster and miR-125a-5p suppress lung tumorigenesis by targeting multiple components of KRAS and NF-kB pathways. Scientific Reports. 2017 Nov 13;7 (1):15441.
11. Peter Magee*, Lei Shi*, Michela Garofalo, Role of microRNAs in chemoresistance. Annals of Translational Medicine, 2015; 3(21): 332.
12. Manuela La Montagna, Lei Shi, Peter Magee, Sudhakar Sahoo, Matteo Fassan, Michela Garofalo. AMPKα loss promotes KRAS-mediated lung tumorigenesis. Cell Death & Differentiation.2021 May 26. DOI: 10.1038/s41418-021-00777-0.
13. Lucy Ginn, Lei Shi, Manuela La Montagna and Michela Garofalo. LncRNAs in Non-Small-Cell Lung Cancer. Non-coding RNA, 2020, 6, 25; DOI:10.3390/ncrna6030025.
14. Srivatsava Naidu, Lei Shi, Michela Garofalo. MicroRNAs in lung tumorigenesis and chemoresistance, American Association Cancer Research Education Book, 2015: 71-74. DOI: 10.1158/AACR.EDB-15-7984.
15. 英国专利:lncRNA ASOs for KRAS Amplified Tumors, 发明人。
Cells期刊特刊Chief Guest Editor、Journal of Immunology Research特刊客座编辑
Frontiers in Cell and Developmental Biology编委
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Oncogene等Springer Nature旗下期刊外审专家
中国细胞生物学学会终身会员、中国生物化学与分子生物学学会终身会员、中国抗癌协会环境肿瘤学会会员、中国毒理学会会员、美国癌症协会会员、欧洲癌症协会会员
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河北北方学院百年校庆优秀校友